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1

Genetic architecture: the shape of the genetic contribution to human traits and disease

Timpson, Nicholas J., Greenwood, Celia M. T., Soranzo, Nicole, Lawson, Daniel J., Richards, J. Brent

Journal:

Nature Reviews Genetics

Year:

2017

Language:

english

File:

PDF, 618 KB

english, 2017

2

Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan

Hollis, Ben, Day, Felix R., Busch, Alexander S., Thompson, Deborah J., Soares, Ana Luiza G., Timmers, Paul R. H. J., Kwong, Alex, Easton, Doug F., Joshi, Peter K., Timpson, Nicholas J., Ong, Ken K., P

Journal:

Nature Communications

Year:

2020

Language:

english

File:

PDF, 974 KB

english, 2020

3

Common variation contributes to the genetic architecture of social communication traits

St Pourcain, Beate, Whitehouse, Andrew J O, Ang, Wei Q, Warrington, Nicole M, Glessner, Joseph T, Wang, Kai, Timpson, Nicholas J, Evans, David M, Kemp, John P, Ring, Susan M, McArdle, Wendy L, Golding

Journal:

Molecular Autism

Year:

2013

Language:

english

File:

PDF, 1.83 MB

english, 2013

4

Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence

St Pourcain, Beate, Skuse, David H, Mandy, William P, Wang, Kai, Hakonarson, Hakon, Timpson, Nicholas J, Evans, David M, Kemp, John P, Ring, Susan M, McArdle, Wendy L, Golding, Jean, Smith, George Dav

Journal:

Molecular Autism

Year:

2014

Language:

english

File:

PDF, 709 KB

english, 2014

5

A genome-wide association meta-analysis identifies new childhood obesity loci

Bradfield, Jonathan P, Taal, H Rob, Timpson, Nicholas J, Scherag, André, Lecoeur, Cecile, Warrington, Nicole M, Hypponen, Elina, Holst, Claus, Valcarcel, Beatriz, Thiering, Elisabeth, Salem, Rany M, S

Journal:

Nature Genetics

Year:

2012

Language:

english

File:

PDF, 400 KB

english, 2012

6

Genetic Determinants of Height Growth Assessed Longitudinally from Infancy to Adulthood in the Northern Finland Birth Cohort 1966

Sovio, Ulla, Bennett, Amanda J., Millwood, Iona Y., Molitor, John, O'Reilly, Paul F., Timpson, Nicholas J., Kaakinen, Marika, Laitinen, Jaana, Haukka, Jari, Pillas, Demetris, Tzoulaki, Ioanna, Molitor

Journal:

Year:

2009

Language:

english

File:

PDF, 227 KB

english, 2009

7

The CHRNA5–A3–B4 Gene Cluster and Smoking: From Discovery to Therapeutics

Lassi, Glenda, Taylor, Amy E., Timpson, Nicholas J., Kenny, Paul J., Mather, Robert J., Eisen, Tim, Munafò, Marcus R.

Journal:

Trends in Neurosciences

Year:

2016

Language:

english

File:

PDF, 1.59 MB

english, 2016

8

Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study

Wootton, Robyn E, Lawn, Rebecca B, Millard, Louise A C, Davies, Neil M, Taylor, Amy E, Munafò, Marcus R, Timpson, Nicholas J, Davis, Oliver S P, Davey Smith, George, Haworth, Claire M A

Journal:

Year:

2018

Language:

english

File:

PDF, 710 KB

english, 2018

9

Genetic association study of BDNF in depression: Finding from two cohort studies and a meta-analysis

Lina Chen, Debbie A. Lawlor, Sarah J. Lewis, Wei Yuan, Mohammad R. Abdollahi, Nicholas J. Timpson, Ian N.M. Day, Shah Ebrahim, George Davey Smith, Yin Y. Shugart

Journal:

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Year:

2008

Language:

english

File:

PDF, 248 KB

english, 2008

10

A powerful approach to sub-phenotype analysis in population-based genetic association studies

Andrew P. Morris, Cecilia M. Lindgren, Eleftheria Zeggini, Nicholas J. Timpson, Timothy M. Frayling, Andrew T. Hattersley, Mark I. McCarthy

Journal:

Genetic Epidemiology

Year:

2010

Language:

english

File:

PDF, 298 KB

english, 2010

11

Adiponectin and its association with bone mass accrual in childhood

Adrian Sayers, Nicholas J Timpson, Naveed Sattar, John Deanfield, Aroon D Hingorani, George Davey-Smith, Jon H Tobias

Journal:

Journal of Bone and Mineral Research

Year:

2010

Language:

english

File:

PDF, 97 KB

english, 2010

12

Refining associations betweenTAS2R38diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children

Nicholas J Timpson, Jon Heron, Ian NM Day, Susan M Ring, Linda M Bartoshuk, Jeremy Horwood, Pauline Emmett, George Davey-Smith

Journal:

Year:

2007

Language:

english

File:

PDF, 684 KB

english, 2007

13

Mendelian Randomization: Application to Cardiovascular Disease

Nicholas J. Timpson, Kaitlin H. Wade, George Davey Smith

Journal:

Current Hypertension Reports

Year:

2012

Language:

english

File:

PDF, 250 KB

english, 2012

14

Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53 221 adults

Debbie A. Lawlor, Roger M. Harbord, Anne Tybjaerg-Hansen, Tom M. Palmer, Jeppe Zacho, Marianne Benn, Nicholas J. Timpson, George Davey Smith, Børge G. Nordestgaard

Journal:

Journal of Internal Medicine

Year:

2011

Language:

english

File:

PDF, 181 KB

english, 2011

15

Genome-Wide Association Scan Allowing for Epistasis in Type 2 Diabetes

Jordana T. Bell, Nicholas J. Timpson, N. William Rayner, Eleftheria Zeggini, Timothy M. Frayling, Andrew T. Hattersley, Andrew P. Morris, Mark I. McCarthy

Journal:

Annals of Human Genetics

Year:

2011

Language:

english

File:

PDF, 276 KB

english, 2011

16

Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI

Shugart, Yin Yao, Chen, Lina, Day, Ian N M, Lewis, Sarah J, Timpson, Nicholas J, Yuan, Wei, Abdollahi, Mohammad Reza, Ring, Sue M, Ebrahim, Shah, Golding, Jean

Journal:

European Journal of Human Genetics

Year:

2009

Language:

english

File:

PDF, 116 KB

english, 2009

17

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

Timpson, Nicholas J, Berry, Diane J, Warrington, Nicole M, Widen, Elisabeth, Hottenga, Jouke Jan, Kaakinen, Marika, Freathy, Rachel M, Mook-Kanamori, Dennis O, Sovio, Ulla, Prokopenko, Inga

Journal:

Nature Genetics

Year:

2010

Language:

english

File:

PDF, 533 KB

english, 2010

18

Common variants in the GDF5-UQCC region are associated with variation in human height

Sanna, Serena, Jackson, Anne U, Nagaraja, Ramaiah, Willer, Cristen J, Chen, Wei-Min, Bonnycastle, Lori L, Shen, Haiqing, Timpson, Nicholas, Lettre, Guillaume, Usala, Gianluca

Journal:

Nature Genetics

Year:

2008

Language:

english

File:

PDF, 407 KB

english, 2008

19

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

Willer, Cristen J, Sanna, Serena, Jackson, Anne U, Scuteri, Angelo, Bonnycastle, Lori L, Clarke, Robert, Heath, Simon C, Timpson, Nicholas J, Najjar, Samer S, Stringham, Heather M

Journal:

Nature Genetics

Year:

2008

Language:

english

File:

PDF, 422 KB

english, 2008

20

How Does Body Fat Influence Bone Mass in Childhood? A Mendelian Randomization Approach

Nicholas J Timpson, Adrian Sayers, George Davey-Smith, Jonathan H Tobias

Journal:

Journal of Bone and Mineral Research

Year:

2009

Language:

english

File:

PDF, 489 KB

english, 2009

21

A Variant in LIN28B Is Associated with 2D:4D Finger-Length Ratio, a Putative Retrospective Biomarker of Prenatal Testosterone Exposure

Sarah E. Medland, Tetyana Zayats, Beate Glaser, Dale R. Nyholt, Scott D. Gordon, Margaret J. Wright, Grant W. Montgomery, Megan J. Campbell, Anjali K. Henders, Nicholas J. Timpson, Leena Peltonen, Die

Journal:

The American Journal of Human Genetics

Year:

2010

Language:

english

File:

PDF, 225 KB

english, 2010

22

Genome-wide Association Study of Three-Dimensional Facial Morphology Identifies a Variant in PAX3 Associated with Nasion Position

Lavinia Paternoster, Alexei I. Zhurov, Arshed M. Toma, John P. Kemp, Beate St. Pourcain, Nicholas J. Timpson, George McMahon, Wendy McArdle, Susan M. Ring, George Davey Smith, Stephen Richmond, David

Journal:

The American Journal of Human Genetics

Year:

2012

Language:

english

File:

PDF, 924 KB

english, 2012

23

Erratum: Adiponectin and its association with bone mass accrual in childhood

Adrian Sayers, Nicholas J Timpson, Naveed Sattar, John Deanfield, Aroon D Hingorani, George Davey-Smith, Jon H Tobias

Journal:

Journal of Bone and Mineral Research

Year:

2012

File:

PDF, 25 KB

2012

24

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study

Nicholas J Timpson, Debbie A Lawlor, Roger M Harbord, Tom R Gaunt, Ian NM Day, Lyle J Palmer, Andrew T Hattersley, Shah Ebrahim, Gordon DO Lowe, Ann Rumley, George Davey Smith

Journal:

Year:

2005

Language:

english

File:

PDF, 97 KB

english, 2005

25

A Common Haplotype of the Glucokinase Gene Alters Fasting Glucose and Birth Weight: Association in Six Studies and Population-Genetics Analyses

Michael N. Weedon, Vanessa J. Clark, Yudong Qian, Yoav Ben-Shlomo, Nicholas Timpson, Shah Ebrahim, Debbie A. Lawlor, Marcus E. Pembrey, Susan Ring, Terry J. Wilkin, Linda D. Voss, Alison N. Jeffery, B

Journal:

The American Journal of Human Genetics

Year:

2006

Language:

english

File:

PDF, 396 KB

english, 2006

26

NetView: A High-Definition Network-Visualization Approach to Detect Fine-Scale Population Structures from Genome-Wide Patterns of Variation

Neuditschko, Markus, Khatkar, Mehar S., Raadsma, Herman W., Timpson, Nicholas John

Journal:

Year:

2012

Language:

english

File:

PDF, 794 KB

english, 2012

27

Recent Findings on the Genetics of Obesity: Is there Public Health Relevance?

Rebecca C. Richmond, Nicholas J. Timpson

Journal:

Current Nutrition Reports

Year:

2012

Language:

english

File:

PDF, 224 KB

english, 2012

28

Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts

Shah Ebrahim, Debbie A. Lawlor, Yoav Ben Shlomo, Nicholas Timpson, Roger Harbord, Mikkel Christensen, Jamil Baban, Matt Kiessling, Ian Day, Tom Gaunt, George Davey Smith

Journal:

Atherosclerosis

Year:

2008

Language:

english

File:

PDF, 120 KB

english, 2008

29

Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: Results of genome-wide association analyses including 4659 European individuals

Iris M. Heid, Peter Henneman, Andrew Hicks, Stefan Coassin, Thomas Winkler, Yurii S. Aulchenko, Christian Fuchsberger, Kijoung Song, Marie-France Hivert, Dawn M. Waterworth, Nicholas J. Timpson, J. Br

Journal:

Atherosclerosis

Year:

2010

Language:

english

File:

PDF, 1.19 MB

english, 2010

30

Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort

Spycher, Ben D., Henderson, John, Granell, Raquel, Evans, David M., Smith, George Davey, Timpson, Nicholas J., Sterne, Jonathan A.C.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2012

Language:

english

File:

PDF, 1.47 MB

english, 2012

31

Does a short breastfeeding period protect from FTO-induced adiposity in children?

GEORGE V. Z. DEDOUSSIS, MARY YANNAKOULIA, NICHOLAS J. TIMPSON, YANNIS MANIOS, STAVROULA KANONI, ROBERT A. SCOTT, CONSTANTINA PAPOUTSAKIS, PANOS DELOUKAS, YANNIS P. PITSILADIS, GEORGE DAVEY-SMITH, JOEL

Journal:

Pediatric Obesity

Year:

2011

Language:

english

File:

PDF, 117 KB

english, 2011

32

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

Hinds, David A, McMahon, George, Kiefer, Amy K, Do, Chuong B, Eriksson, Nicholas, Evans, David M, St Pourcain, Beate, Ring, Susan M, Mountain, Joanna L, Francke, Uta, Davey-Smith, George, Timpson, Nic

Journal:

Nature Genetics

Year:

2013

Language:

english

File:

PDF, 800 KB

english, 2013

33

Does Bone Resorption Stimulate Periosteal Expansion? A Cross-Sectional Analysis of β-C-telopeptides of Type I Collagen (CTX), Genetic Markers of the RANKL Pathway, and Periosteal Circumference as Measured by pQCT

Kemp, John P, Sayers, Adrian, Paternoster, Lavinia, Evans, David M, Deere, Kevin, St Pourcain, Beate, Timpson, Nicholas J, Ring, Susan M, Lorentzon, Mattias, Lehtimäki, Terho, Eriksson, Joel, Kähönen,

Journal:

Journal of Bone and Mineral Research

Year:

2014

Language:

english

File:

PDF, 499 KB

english, 2014

34

Effect of low thyroid hormone bioavailability on childhood cognitive development: data from the Avon Longitudinal Study of Parents and Children birth cohort

Taylor, Peter, Okosieme, Onyebuchi, Sayers, Adrian, Pearce, Elizabeth, Gregory, John, Lazarus, John, Panicker, Vijay, Channon, Sue, Timpson, Nicholas, Dayan, Colin

Journal:

Year:

2014

Language:

english

File:

PDF, 62 KB

english, 2014

35

Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes

Granell, Raquel, Henderson, A. John, Timpson, Nicholas, St. Pourcain, Beate, Kemp, John P., Ring, Susan M., Ho, Karen, Montgomery, Stephen B., Dermitzakis, Emmanouil T., Evans, David M., Sterne, Jonat

Journal:

Journal of Allergy and Clinical Immunology

Year:

2013

Language:

english

File:

PDF, 794 KB

english, 2013

36

A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

Timpson, Nicholas J., Walter, Klaudia, Min, Josine L., Tachmazidou, Ioanna, Malerba, Giovanni, Shin, So-Youn, Chen, Lu, Futema, Marta, Southam, Lorraine, Iotchkova, Valentina, Cocca, Massimiliano, Hua

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 541 KB

english, 2014

37

Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease

Flint, Jonathan, Timpson, Nicholas, Munafò, Marcus

Journal:

Trends in Neurosciences

Year:

2014

Language:

english

File:

PDF, 622 KB

english, 2014

38

Coordinated Genetic Scaling of the Human Eye: Shared Determination of Axial Eye Length and Corneal Curvature

Guggenheim, Jeremy A., Zhou, Xin, Evans, David M., Timpson, Nicholas J., McMahon, George, Kemp, John P., St Pourcain, Beate, Northstone, Kate, Ring, Susan M., Fan, Qiao, Wong, Tien-Yin, Cheng, Ching Y

Journal:

Investigative Ophthalmology & Visual Science

Year:

2013

Language:

english

File:

PDF, 266 KB

english, 2013

39

Heritability and genome-wide analyses of problematic peer relationships during childhood and adolescence

St Pourcain, Beate, Haworth, C. M. A., Davis, O. S. P., Wang, Kai, Timpson, Nicholas J., Evans, David M., Kemp, John P., Ronald, Angelica, Price, Tom, Meaburn, Emma, Ring, Susan M., Golding, Jean, Hak

Journal:

Year:

2015

Language:

english

File:

PDF, 575 KB

english, 2015

40

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors

Burgess, Stephen, Scott, Robert A., Timpson, Nicholas J., Davey Smith, George, Thompson, Simon G.

Journal:

European Journal of Epidemiology

Year:

2015

Language:

english

File:

PDF, 429 KB

english, 2015

41

Using inactivating mutations to provide insight into drug action

Corbin, Laura J, Timpson, Nicholas J

Journal:

Genome Medicine

Year:

2015

Language:

english

File:

PDF, 312 KB

english, 2015

42

Shared Genetic Influences Between Attention-Deficit/Hyperactivity Disorder (ADHD) Traits in Children and Clinical ADHD

Stergiakouli, Evie, Martin, Joanna, Hamshere, Marian L., Langley, Kate, Evans, David M., St Pourcain, Beate, Timpson, Nicholas J., Owen, Michael J., O'Donovan, Michael, Thapar, Anita, Davey Smith, Geo

Journal:

Journal of the American Academy of Child & Adolescent Psychiatry

Year:

2015

Language:

english

File:

PDF, 298 KB

english, 2015

43

AVPR1A and SLC6A4 Polymorphisms in Choral Singers and Non-Musicians: A Gene Association Study

Morley, Andrew P., Narayanan, Madan, Mines, Rebecca, Molokhia, Ashraf, Baxter, Sebastian, Craig, Gavin, Lewis, Cathryn M., Craig, Ian, Timpson, Nicholas John

Journal:

Year:

2012

Language:

english

File:

PDF, 165 KB

english, 2012

44

A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels

Richards, J. Brent, Waterworth, Dawn, O'Rahilly, Stephen, Hivert, Marie-France, Loos, Ruth J. F., Perry, John R. B., Tanaka, Toshiko, Timpson, Nicholas John, Semple, Robert K., Soranzo, Nicole, Song,

Journal:

Year:

2009

Language:

english

File:

PDF, 661 KB

english, 2009

45

Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates

Evans, David M., Brion, Marie Jo A., Paternoster, Lavinia, Kemp, John P., McMahon, George, MunafÃ², Marcus, Whitfield, John B., Medland, Sarah E., Montgomery, Grant W., Timpson, Nicholas J., St. Pourc

Journal:

Year:

2013

Language:

english

File:

PDF, 675 KB

english, 2013

46

Genetic Markers of Adult Obesity Risk Are Associated with Greater Early Infancy Weight Gain and Growth

Elks, Cathy E., Loos, Ruth J. F., Sharp, Stephen J., Langenberg, Claudia, Ring, Susan M., Timpson, Nicholas J., Ness, Andrew R., Davey Smith, George, Dunger, David B., Wareham, Nicholas J., Ong, Ken K

Journal:

Year:

2010

Language:

english

File:

PDF, 357 KB

english, 2010

47

Genome-Wide Association Study Identifies Four Loci Associated with Eruption of Permanent Teeth

Geller, Frank, Feenstra, Bjarke, Zhang, Hao, Shaffer, John R., Hansen, Thomas, Esserlind, Ann-Louise, Boyd, Heather A., Nohr, Ellen A., Timpson, Nicholas J., Fatemifar, Ghazaleh, Paternoster, Lavinia,

Journal:

Year:

2011

Language:

english

File:

PDF, 318 KB

english, 2011

48

The Effect of Elevated Body Mass Index on Ischemic Heart Disease Risk: Causal Estimates from a Mendelian Randomisation Approach

Nordestgaard, Børge G., Palmer, Tom M., Benn, Marianne, Zacho, Jeppe, Tybjærg-Hansen, Anne, Davey Smith, George, Timpson, Nicholas J., Minelli, Cosetta

Journal:

Year:

2012

Language:

english

File:

PDF, 788 KB

english, 2012

49

Common Variants in Left/Right Asymmetry Genes and Pathways Are Associated with Relative Hand Skill

Brandler, William M., Morris, Andrew P., Evans, David M., Scerri, Thomas S., Kemp, John P., Timpson, Nicholas J., St Pourcain, Beate, Smith, George Davey, Ring, Susan M., Stein, John, Monaco, Anthony

Journal:

Year:

2013

Language:

english

File:

PDF, 412 KB

english, 2013

50

The CRP genotype, serum levels and lung function in men: the Caerphilly Prospective Study

Bolton, Charlotte E., Schumacher, Wiebke, Cockcroft, John R., Timpson, Nicholas J., Smith, George Davey, Gallacher, John, Rumley, Anne, Lowe, Gordon D., Ebrahim, Shah, Shale, Dennis J., Ben‑Shlomo, Yo

Journal:

Clinical Science

Year:

2011

Language:

english

File:

PDF, 123 KB

english, 2011